1η ΔΗΜΟΣΙΕΥΣΗ ΤΟΥ ΕΠΙΣΤΗΜΟΝΙΚΟΥ ΣΥΜΒΟΥΛΙΟΥ ΤΗΣ BIOGENEA PHARMACEUTICALS ΣΤΟ ΣΥΝΕΔΡΙΟ ΤΟΥ ΔΙΕΘΝΟΥΣ ΟΡΓΑΝΙΣΜΟΥ ΚΥΤΤΑΡΙΚΩΝ ΘΕΡΑΠΕΙΩΝ ISCT 2014

LWPQ: an in silico designed multi-core super-agonist motif-like regulatory peptide for the activation of human stem cell transcripts using an integrated computational approach

N. Grigoriadis

 ,  

I. Grigoriadis

Biogenea pharmaceuticals, Thessaloniki, Greece

199

DOI: http://dx.doi.org/10.1016/j.jcyt.2014.01.200

Full TextThe role of KIT ligand CXC chemokine receptor CXCR4, fibroblast growth factors and their receptors (FGFRs), Notch or its ligand Jagged1 and retinoic acid (RA) signaling in determining the fate of these cells in the regulation of normal hematopoietic stem cells is well-known An increasing amount of evidence from experimental and computational bioinformatic analysis suggests that there are many domains in DNA sequences that remain evolutionarily conserved. In some cases, these conserved patterns in a collection of unaligned DNA and protein sequences present the same functional and regulatory properties and are significant for the molecular role of these sequences.